Magnetoresistive biochips

Membrane biochips.

Membrane-bound proteins represent the single most important class of drug targets. This article discusses the issues surrounding fabrication of membrane-protein microarrays by conventional robotic pin printing techniques. Ligand binding selectivity and specificity to G protein-coupled receptor (GPCR) microarrays are presented. The potential applications of these arrays for drug screening are di...

Biosensors and Biochips

Digital-Microfluidic Biochips

D igital-micro uidic biochips (DMFBs) are revolutionizing laboratory procedures for point-of-care clinical diagnostics, environmental monitoring, and drug discovery. DMFBs allow bioassay protocols to be scaled down to droplet size. They’re executed by enabling precise control of discrete droplets using a patterned array of electrodes. Biochemistry’s inherent complexity means that operational er...

Hand-Held Magnetoresistive Transducer

The initial design of a vertical magnetoresistive head in a hand-held wand for reading magnetically encoded price tags and credit cards is discussed. The performance of the head (e.g., resolution, signal shape and amplitude, and signal-to-noise ratio) is analytically and experimentally evaluated as a function of the configuration of the sensor, head-to-medium interface, and sensor processing an...

Magnetoresistive Emulsion Analyzer

We realize a magnetoresistive emulsion analyzer capable of detection, multiparametric analysis and sorting of ferrofluid-containing nanoliter-droplets. The operation of the device in a cytometric mode provides high throughput and quantitative information about the dimensions and magnetic content of the emulsion. Our method offers important complementarity to conventional optical approaches invo...